2018, Northwest Missouri State University, Jaroll's review: "Dramamine 50 mg. Buy Dramamine.".
In very small doses purchase 50 mg dramamine mastercard, from the one-twenty-fifth to the one-tenth of a grain of the resin buy 50 mg dramamine, it is said to cure some cases of habitual constipation buy generic dramamine 50 mg on line, those depending upon extreme atonicity buy 50 mg dramamine with mastercard. Locke says the remedy is not available when there is a high degree of inflammation, with great vascular excitement. The indications for rhus toxicodendron will often be found present with the indications for this agent. It has alterative properties and is useful in some cases of skin disease of a chronic character, but we have superior remedies. Ellingwood’s American Materia Medica, Therapeutics and Pharmacognosy - Page 243 Specific Symptomatology—Soreness of muscles, muscular aching, a bruised sensation, soreness from violent muscular exertion, soreness from bruises and strains, soreness and muscular aching from cold and exposure, relaxed mucous membranes, dark blue membranes from venous stasis, veins dilated, relaxed, enlarged, and full—varicosis. Therapy—Internally it is given with the above indications as a remedy for sore throat of whatever kind, with feeling of extreme soreness, and with dark-colored membranes. It is used in tonsillitis and diphtheria, in phlegmonous ulcerations of the mouth and throat, and in acute catarrh. If there is hemorrhage from the post-nasal cavity, or from the teeth, or from spongy gums, it is a useful remedy. It is valuable when there is excessive catarrhal discharge from dark, relaxed mucous membranes, and in catarrhal or watery diarrhea with a tendency to passive hemorrhage of dark blood. It has conspicuous virtue in the treatment of hemorrhoids with the specific indications. The fluid extract in fifteen drop doses every two hours will quickly effect a cure in recent cases, and will greatly benefit chronic cases, its influence being greatly enhanced if combined with collinsonia. In relaxation of the mucous membranes of the rectum and in prolapse of the bowel, it is useful. In these cases the distilled extract should be applied externally while the fluid extract is given internally. It is a good remedy in relaxation of the vaginal walls with leucorrhea, and in catarrh of the womb, also in passive hemorrhages from these parts, especially if there be soreness or extreme tenderness. Externally the distilled extract is of first importance in soreness of the muscles, or aching of parts. In the general aching, lameness and muscular soreness, following a severe confinement—a source of extreme discomfort, often greatly retarding recovery-this agent applied hot will give immediate relief, a measure it is cruel to neglect to advise, in these cases, as it acts at once. In lame and sore breasts it may be applied, to immediately relieve the soreness, but other remedies should be given for acute inflammatory action. Its indications would suggest it as an excellent remedy in rheumatism, Ellingwood’s American Materia Medica, Therapeutics and Pharmacognosy - Page 244 being of value externally and in conjunction with other remedies. Ten grains of menthol dissolved in four ounces of the distilled extract applied to a burn will stop the pain at once and will promote the healing. It is best applied by saturating a soft cloth with which the burned surface may be covered. We insert it here, that it may be kept before the minds of our readers until its properties are determined. In some parts of California, and New Mexico, there is but little fear of tetanus, as they administer this remedy freely, almost ad libitum. It is not poisonous, but few if any unpleasant results having been observed from its action. Several physicians have used the remedy in chorea, and claim that it is superior to other agents in certain persistent, otherwise intractable cases. It has controlled the spasms of meningitis, and will probably be an important addition to the specific medication of that disease. In puerperal convulsions, reports are not sufficient to direct us in its application. It has been observed that when palpitation of the heart, or serious disturbance of the action of this organ from a high degree of nervous excitement is present, this agent is curative. Physiological Action—Black Hellebore, when locally applied, causes irritation of mucous membranes and of the conjunctiva, inducing redness, swelling and increased secretion.
The various 26 Cunningham clinical and histological grading systems consistently demonstrate improvement (21–23) generic 50 mg dramamine overnight delivery. Excellent dramamine 50 mg with visa, good generic dramamine 50 mg overnight delivery, or fair responses were obtained in 5% buy generic dramamine 50mg on-line, 21%, and 42% of 76 tretinoin emollient cream–treated patients and in 0%, 11%, and 32% of 72 vehicle-treated subjects—results that were clinically obvious, cosmetically meaningful, and statistically significant (p 0. The individual parame- ters of fine wrinkling, roughness, and mottled pigmentation are consistently im- proved and can be observed and quantitated by the subject. The investigator or a third party can confirm this utility with any and all of the clinical grading systems, visual analogue scoring, clinical panel assessment, fluorescent and po- larized photography, optical profilometry, and histological assessments described above. Some months of treatment are necessary to reach meaningful clinical effect and the treatment, while generally adequately tolerated, does frequently produce some undesired dryness and erythema especially at the onset. Roughness, fine wrinkles, and mottled pigmentation respond but meaningful improvements in skin function, such as elasticity have not been consistently described. Thus, the reparative abilities of retinoids may not be limited only to photodamage. Isotretinoin has also been adequately documented in double-blind, vehicle- controlled trials to improve the same parameters of photoaging as tretinoin and appears to be well tolerated. It most likely will be studied and proven efficacious in reversing some of the stigmata of photoaging. Tazarotene, another recently studied retinoid, has been shown to be effec- tive in psoriasis and acne will likely be effective in photoaging (27). Retinol, the prototypic retinoid, is the alcohol of retinoic acid and has been shown to be somewhat active in animal models of photodamage. Data to substantiate this cosmetic claim (not the same as pharma- ceutical efficacy substantiation) are not included in the advertisements. Hormones and Vitamins As many hormone and vitamin deficiencies adversely affect the skin and as many of the skin functions and structures have been shown to be affected by hormonal Photoaging 27 or vitamin treatment, it is surprising that there has not recently been more quality research in the area of hormonal and vitamin effects or attention focused on the therapeutic use of androgen, thyroid, or growth hormones topically applied in photoaging. Androgens Androgens play a major role in skin physiology and are especially important in regulation of hair growth and sebum secretion. Less is known about their anabolic capabilities in skin but one would conclude that they should produce beneficial effects on aging and photoaging skin although conclusive proof is presently lacking. Estrogens A modest literature does exist, however, supporting the utility of estrogens in reversing at least some of the sequelae of skin aging. Clinically, improvement of elasticity, firmness, skin moisture, vascularization, and wrinkling were noted. A randomized, double-blind study of 54 women aged 52 to 70 years with moderate-to-severe facial cutaneous aging compared treatment with either 1 g Premarin cream (0. A statistically significant difference in skin thickness measured by B-scan ultrasonic echography was demonstrated at week 24 in the Premarin-treated group. Clinically, significant improve- 28 Cunningham ments in roughness, laxity, and mottled hyperpigmentation were noted by the investigator, but no differences from baseline or between the two groups were noted in subjects’ self-evaluations of overall facial appearance or wrinkling of the crow’s feet area. Although pre- and posthormone determinations were not obtained in this study, a significant difference from baseline in the vaginal matu- ration index was noted in the Premarin-treated group, indicating probable sys- temic effect. Both groups demonstrated significant decreases of wrinkle depth measured by optical profilimetry as well as clinical improvement in elasticity and firmness of the skin. No evidence of systemic hormonal effect was noted except for an increase in prolactin levels. Vitamins Vitamin D Many vitamin D analogues have demonstrated effects on epidermal cells and fibroblasts and they have achieved quick acceptance in treatment of psoriasis. As some of their properties resemble those of retinoids, modulation of epidermal differentiation is possible and should be investigated in photoaging. Vitamin C As with claims for retinol in cosmetic products, the claims made for topical vita- min C are still more cosmetic than documented pharmaceutical. Vitamin E Vitamin E is an antioxidant in many systems and has been proposed, studied, and promoted for a large number of diverse systemic and skin conditions (33). On a theoretical basis, the concept of utility of the antioxidant effect of vitamin E is appealing, but, although the literature is voluminous, it is not completely convincing of a pharmaceutical effect in most conditions including skin disease, photoprotection, or photoaging. A 10-day study by the same investigators claimed Photoaging 29 enhanced skin smoothness with topical vitamin E. In a pilot study, a 25% increase in skin thickness was noted, comprised of both epidermal and dermal contributions.
Another trial looked at a dosage of 32 mg per day buy 50 mg dramamine otc, and found that the progesterone cream raised serum levels but did not change hot flashes discount 50 mg dramamine with amex, mood generic 50 mg dramamine, or sexual drive order dramamine 50mg free shipping. Needless to say, this isn’t helping my marriage, and things are slowly falling apart. Donna describes fluid retention and lousy sleep before her period, no libido, and no energy to run or practice yoga. Treatment protocol: Donna has classic symptoms of low progesterone, including retained fluid, heavier periods, insomnia, poor self-soothing and decreased stress resilience. We started her on progesterone cream, 20 mg per night rubbed into the inner surface of her upper arms. Results: Within four weeks, the progesterone cream had decreased her insomnia, menstrual flow, and bloating. After eight weeks, Donna reported dramatic changes that not only improved her life but also positively impacted everyone around her. For the first time in years, she told me that she felt home again in her body, embodied and in control. She felt motivated to get back into yoga and running and possessed the mettle to cope with her daughters again. When little things happened, she didn’t fly off the handle, but managed them with grace and ease. I often find that small doses of progesterone are the small hinges that swing big doors for perimenopausal women. Taken orally, it is identical to the progesterone you’ve always made while cycling. A word of caution: use Prometrium, not Provera (medroxyprogesterone acetate), the most common progestin, or synthetic form, of progesterone. Many physicians prescribe progestins to patients suffering from irregular periods, fibroids, and/or heavy bleeding. Though the words frequently are used interchangeably by physicians and the media, progesterone and progestins are different biochemically, which means they have very different effects on the body. In study after study, Provera has been shown to increase the risk for breast cancer, depression, weight gain, blood clots, and cardiovascular disease (stroke and heart attacks). In the best evidence of progestins and heart disease, women aged forty-five to sixty-four were randomly assigned to receive Provera, Prometrium, or a placebo. One study, of more than eighty thousand women followed for eight years, showed no increased risk of breast cancer when using 40 Prometrium. An important point about progesterone is that one of its main security jobs is to protect the endometrial lining from overgrowth, precancer (hyperplasia), and cancer. The only bioidentical progesterone shown to prevent buildup in the uterine lining is Prometrium. Prometrium, taken in 100 mg or 200 mg tablets, can do anything progestins can do, but better and more safely. Women with peanut allergies might consider compounding natural progesterone in another base oil, which would have to be ordered by a physician who’s comfortable working with a compounding pharmacy. The only situation in which progestins might be appropriate is for incarcerated sex offenders, because progestins removes sex drive in both men and women. Her periods are heavy, and as a result, she has low ferritin, which is the most sensitive indicator of iron levels. Because of that and her disrupted sleep, I wrote a prescription for Prometrium, which acts as a somnolent. She and her husband have learned to take advantage of every morsel of increased interest. It’s more complicated, as I described earlier, and relates to progesterone “resistance. Magnesium, 200 mg/day, helps with bloating, as does vitamin B6, 50 to 100 43 mg/day. B is involved in the production of many neurotransmitters, including serotonin, which controls mood, sleep, and appetite, and dopamine, which controls pleasure and satisfaction. Consumption of excess refined carbohydrates causes loss of magnesium through the urine. I’m not sure why this works, but it may reduce cortisol—less stress, more progesterone.